- Title
- Common variants at 6p21.1 are associated with large artery atherosclerotic stroke
- Creator
- Holliday, Elizabeth G.; Maguire, Jane M.; Malik, Rainer; McEvoy, Mark; Biros, Erik; Lewis, Martin D.; Lincz, Lisa F.; Peel, Roseanne; Oldmeadow, Christopher; Smith, Wayne; Moscato, Pablo; Barlera, Simona; Evans, Tiffany-Jane; Bevan, Steve; Bis, Joshua C.; Boerwinkle, Eric; Boncoraglio, Giorgio B.; Brott, Thomas G.; Scott, Rodney J.; Levi, Christopher; Attia, John; Koblar, Simon A.; Jannes, Jim; Sturm, Jonathan W.; Hankey, Graeme J.; Baker, Ross; Golledge, Jonathan; Parsons, Mark W.
- Relation
- Nature Genetics Vol. 44, p. 1147-1153
- Publisher Link
- http://dx.doi.org/10.1038/ng.2397
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2012
- Description
- Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR) = 1.62, P = 3.9 × 10−8) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR = 1.15, P = 3.9 × 10−4; discovery and replication combined OR = 1.21, P = 4.7 × 10−8). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke.
- Subject
- Genome-wide association studies
- Identifier
- http://hdl.handle.net/1959.13/1041721
- Identifier
- uon:13951
- Identifier
- ISSN:1061-4036
- Language
- eng
- Full Text
- Reviewed
- Hits: 15879
- Visitors: 11439
- Downloads: 1347
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT03 | Author final version | 1 MB | Adobe Acrobat PDF | View Details Download |